Table of Contents
Introduction of thiazole
Introduction of thiazole, The term ‘thiazole‘ refer to a large family is derivatives. It has a molecular formula of C3H3NS. It can be related to the simple tertiary aliphatic amines. Thiazole, an organic compound with a five-membered ring containing both nitrogen and sulfur atoms, plays a crucial role in various fields such as pharmaceuticals, agrochemicals, and materials science. Its unique structure and diverse chemical properties have made it a valuable building block for the synthesis of numerous biologically active compounds.
![Introduction of thiazole](https://www.mimprovement.com/wp-content/uploads/2023/07/image-15.png)
Thiazole derivatives have exhibited promising pharmacological activities, including antimicrobial, anticancer, anti-inflammatory, and anticonvulsant properties. These compounds have been extensively studied for their potential applications in drug discovery and development.
Physical properties of thiazole
1. Thiazole is a pale-yellow coloured liquid with a boiling point of 117°C.
2. It has a pyridine like odour.
3. This ring structure is found in vitamin B, & also in some antibiotics.
4. It is used for preparing different sulpha drugs.
Synthesis of thiazole
1. Gabriel synthesis (from alpha-acyl amino ketones)
Alpha-acyl amino ketones undergo cyclization in presence of P2S5 and strong mineral acid H2SO4 followed by dehydration.
2. Hantzsch thiazole synthesis
Condensation of alpha-halo ketones with thioamides.
![](https://www.mimprovement.com/wp-content/uploads/2023/07/image-17.png)
3. Cook–Heilbron thiazole synthesis
Condensation of alpha-aminonitrile with CS2.
![](https://www.mimprovement.com/wp-content/uploads/2023/07/image-18.png)
Chemical reactions of thiazole
1. Reactions with acids (Protonation)
Thiazole accepts proton, act as base and forms thiazolium cation.
![](https://www.mimprovement.com/wp-content/uploads/2023/07/image-19.png)
2. Reduction
Thiazole ring is resistant to many reducing agents. However, raney nickel reduces it and opens the ring.
![](https://www.mimprovement.com/wp-content/uploads/2023/07/image-20.png)
3. Bromination
4. Nitration
Medicinal uses of thiazole
1. It is used for manufacturing biocides, fungicides, pharmaceutical & dyes.
2. Thiabendazole is used for treating ear infection.
3. Thiamine is used as beri-beri.
4. It may also be used to treat pinworm, hookworm & roundworm infections.
5. Sulfathiazole is a short acting sulfonamide antibiotic.
Hello mimprovement.com admin, You always provide great information and insights.